Current Issue : July - September Volume : 2018 Issue Number : 3 Articles : 6 Articles
It is known that the dietary pattern and macronutrients profile may influence the expression and secretion of inflammatory\nbiomarkers, and the low-grade inflammation is associated with the manifestation of noncommunicable chronic diseases.\nTherefore, this review aimed to present and discuss the role of dietary patterns and macronutrients on the variation of inflammatory\nmarkers related to NCD risk. Scientific evidences within the last five years based on clinical trials, case-controls,\ncohorts, and cross-sectional studies indicate that normocaloric, carbohydrate-moderated, low-glycemic index, proteinmoderated,\nmonounsaturated and polyunsaturated fatty acid-rich, omega-3, and low-saturated fat diets display positive effects\non the inflammatory state, both in healthy individuals and in those with cardiovascular risk, although the second group seems\nto benefit more from changes in the dietary profile....
The oxidative damage caused by reactive oxygen species (ROS) leads various diseases such as cancer, coronary heart diseases, renal failure, diabetes, ageing etc. There is an increasing interest in natural antioxidants due to the safety and toxicity problems of synthetic antioxidant. In this study, antioxidant potential of hot water extract of green seaweed Ulva faciata was analyzed by 1, 1- diphenyl-2-picrylhydrazyl (DPPH), superoxide radical scavenging, reducing power and metal chelating assay. Hot water extract exhibited the excellent antioxidant activity against DPPH and superoxide radical assay. This study proved that hot water extract of U. faciata is a powerful antioxidant and it can be used for treating various human diseases....
Moringa oleifera Lam. (M. oleifera), which belongs to the Moringaceae family, is a perennial\ndeciduous tropical tree, and native to the south of the Himalayan Mountains in northern\nIndia. M. oleifera is rich in proteins, vitamin A, minerals, essential amino acids, antioxidants,\nand flavonoids, as well as isothiocyanates. The extracts from M. oleifera exhibit multiple nutraceutical\nor pharmacological functions including anti-inflammatory, antioxidant, anti-cancer, hepatoprotective,\nneuroprotective, hypoglycemic, and blood lipid-reducing functions. The beneficial functions of\nM. oleifera are strongly associated with its phytochemicals such as flavonoids or isothiocyanates\nwith bioactivity. In this review, we summarize the research progress related to the bioactivity\nand pharmacological mechanisms of M. oleifera in the prevention and treatment of a series of\nchronic diseasesââ?¬â?including inflammatory diseases, neuro-dysfunctional diseases, diabetes, and\ncancersââ?¬â?which will provide a reference for its potential application in the prevention and treatment\nof chronic diseases or health promotion....
The lichens are being used as nutraceuticals by different cultures across the world. With this in mind, our attention was drawn towards determination of nutraceutical active lichens. As a result we have evaluated the pharmaceutically active profile of lichens, Graphis ajarekarii and Parmotrema tinctorum. The different extracts from lichens, G. ajarekarii and P. tinctorum were evaluated for their antioxidant (DPPH, ABTS and superoxide radical assays), toxicity (in male albino rats), hypoglycaemic (oral glucose tolerance test in rats) and antidiabetic (Streptozotocin (STZ) induced diabetes in rats) studies. Among all the tested extracts, the ethyl acetate extract from G. ajarekarii (Ga-EA) and P. tinctorum (Pt-EA) were active against free radicals and diabetes. The IC50 values of DPPH, ABTS and superoxide radicals of Ga-EA were found to be 62, 54 and 59 µg/mL, respectively, while Pt-EA were 60, 71 and 60 µg/mL, respectively. In addition, the LD50 values of hydroalcoholic extracts from G. ajarekarii and P. tinctorum were found to be ˂2000 mg/kg b.w. Oral administration of Pt-EA and Ga-EA extracts (200 mg/kg b.w) reduced the plasma glucose levels in normal, oral glucose loaded and STZ-induced diabetic rats significantly within 240 and 360 min, respectively. This toxicopharmacological study revealed that the dietary consumption of lichens, G. ajarekarii and P. tinctorum has antidiabetic aptitude in relationship with their antioxidant ability....
Patients with celiac disease (CD) frequently suffer from iron deficiency anemia (IDA)\nand may benefit from iron supplementation. However, intolerance to iron sulfate and duodenal\natrophy could reduce the efficacy of this supplementation. This study evaluated the efficacy of\na new sucrosomial iron formulation in patients with CD. Consecutive patients with CD and IDA\nwere divided into two groups: patients with a known intolerance to iron sulfate were treated with\nsucrosomial iron (30 mg of iron/day), while those receiving iron supplementation for the first time\nwere assigned to iron sulfate (105 mg of iron/day). Forty-three patients were enrolled (38 females,\nmean age 49 �± 9 years). After a follow-up of 90 days both groups showed an increase in Hb levels\ncompared to baseline (+10.1% and +16.2% for sucrosomial and sulfate groups, respectively), and a\nsignificant improvement in all iron parameters, with no statistical difference between the two groups.\nPatients treated with sucrosomial iron reported a lower severity of abdominal symptoms, such as\nabdominal and epigastric pain, abdominal bloating, and constipation, and a higher increase in general\nwell-being (+33% vs. +21%) compared to the iron sulfate group. Sucrosomial iron can be effective\nin providing iron supplementation in difficult-to-treat populations, such as patients with CD, IDA,\nand known intolerance to iron sulfate....
Micronutrient deficiencies occur in segments of the adult population in the United States.\nMultivitamin/multimineral supplements (MVMS) are widely used by this population, which reduces\ninadequacies in micronutrient intake, but the potential for exceeding tolerable upper intake levels\nin others should be considered. There are concerns associated with the excessive intake of certain\nnutrients, particularly folic acid, and potential untoward consequences. The advent of nutrigenomics\nand the enhanced ability to directly study the interactions between nutrition and genetic variants\nand expression will allow for the conduct of more targeted studies with specific endpoints and\nmay ultimately lead to progress in the field of personalized nutrition. The role of MVMS in health\nmaintenance and chronic disease prevention remains controversial. Conducting studies in this area\nhas been hampered by, among other factors, inconsistent definitions of MVMS, ranging from as\nfew as three vitamins to broad-spectrum products containing more than two dozen vitamins and\nminerals. Results from some observational studies and large-scale, randomized, controlled trials\nsuggest that MVMS may reduce the risk of some forms of cancer and, potentially, cardiovascular\ndisease. The ongoing COcoa Supplement and Multivitamin Outcomes Study (COSMOS) is expected\nto build on this research and provide additional insights into these areas....
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